Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad
Fetuses at risk of premature delivery are now routinely exposed to maternal treatment with synthetic glucocorticoids. In randomized clinical trials, these substantially reduce acute neonatal systemic morbidity, and mortality, after premature birth and reduce intraventricular hemorrhage. However, the...
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| Format: | Book |
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Hindawi Limited,
2012-01-01T00:00:00Z.
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| 001 | doaj_300fd5c0f61a41b2a3d1c2dcbb86d07c | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Laura Bennet |e author |
| 700 | 1 | 0 | |a Joanne O. Davidson |e author |
| 700 | 1 | 0 | |a Miriam Koome |e author |
| 700 | 1 | 0 | |a Alistair Jan Gunn |e author |
| 245 | 0 | 0 | |a Glucocorticoids and Preterm Hypoxic-Ischemic Brain Injury: The Good and the Bad |
| 260 | |b Hindawi Limited, |c 2012-01-01T00:00:00Z. | ||
| 500 | |a 2090-2727 | ||
| 500 | |a 2090-2735 | ||
| 500 | |a 10.1155/2012/751694 | ||
| 520 | |a Fetuses at risk of premature delivery are now routinely exposed to maternal treatment with synthetic glucocorticoids. In randomized clinical trials, these substantially reduce acute neonatal systemic morbidity, and mortality, after premature birth and reduce intraventricular hemorrhage. However, the overall neurodevelopmental impact is surprisingly unclear; worryingly, postnatal glucocorticoids are consistently associated with impaired brain development. We review the clinical and experimental evidence on how glucocorticoids may affect the developing brain and highlight the need for systematic research. | ||
| 546 | |a EN | ||
| 690 | |a Gynecology and obstetrics | ||
| 690 | |a RG1-991 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pregnancy, Vol 2012 (2012) | |
| 787 | 0 | |n http://dx.doi.org/10.1155/2012/751694 | |
| 787 | 0 | |n https://doaj.org/toc/2090-2727 | |
| 787 | 0 | |n https://doaj.org/toc/2090-2735 | |
| 856 | 4 | 1 | |u https://doaj.org/article/300fd5c0f61a41b2a3d1c2dcbb86d07c |z Connect to this object online. |