Preclinical Evaluation of Long-Acting Emtricitabine Semi-Solid Prodrug Nanoparticle Formulations

• Main Authors: Paul Curley (Author), James J. Hobson (Author), Neill J. Liptrott (Author), Edward Makarov (Author), Amer Al-khouja (Author), Lee Tatham (Author), Christopher A. W. David (Author), Helen Box (Author), Megan Neary (Author), Joanne Sharp (Author), Henry Pertinez (Author), David Meyers (Author), Charles Flexner (Author), Caren L. Freel Meyers (Author), Larisa Poluektova (Author), Steve Rannard (Author), Andrew Owen (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long-acting injectable (LAI) formulations promise to deliver patient benefits by overcoming issues associated with non-adherence. A preclinical assessment of semi-solid prodrug nanoparticle (SSPN) LAI formulations of emtricitabine (FTC) is reported here. Pharmacokinetics over 28 days were assessed i...