Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

• Main Authors: Akira Nakajima (Author), Tohru Yamakuni (Author), Mitsuya Haraguchi (Author), Naoki Omae (Author), Si-Young Song (Author), Chieko Kato (Author), Osamu Nakagawasai (Author), Takeshi Tadano (Author), Akihito Yokosuka (Author), Yoshihiro Mimaki (Author), Yutaka Sashida (Author), Yasushi Ohizumi (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice. Keywords:: Alzheimer's disease, cholinergic neuron, nobiletin

Item Description

1347-8613
10.1254/jphs.SC0070155