Nonocarbolines A-E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia
During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, <i>Nonomuraea</i> sp. 1808210CR was found to produce five unprecedented <i>β</i>-carboline derivatives, nonocarbolines A−E (<b>1−5</b>). Their...
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| Format: | Book |
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MDPI AG,
2020-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_31c42cfe7f984c0aa32b7bf0a297e3a1 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Gian Primahana |e author |
| 700 | 1 | 0 | |a Chandra Risdian |e author |
| 700 | 1 | 0 | |a Tjandrawati Mozef |e author |
| 700 | 1 | 0 | |a Enge Sudarman |e author |
| 700 | 1 | 0 | |a Matthias Köck |e author |
| 700 | 1 | 0 | |a Joachim Wink |e author |
| 700 | 1 | 0 | |a Marc Stadler |e author |
| 245 | 0 | 0 | |a Nonocarbolines A-E, <i>β</i>-Carboline Antibiotics Produced by the Rare Actinobacterium <i>Nonomuraea</i> sp. from Indonesia |
| 260 | |b MDPI AG, |c 2020-03-01T00:00:00Z. | ||
| 500 | |a 2079-6382 | ||
| 500 | |a 10.3390/antibiotics9030126 | ||
| 520 | |a During the course of our ongoing screening for novel biologically active secondary metabolites, the rare Actinobacterium, <i>Nonomuraea</i> sp. 1808210CR was found to produce five unprecedented <i>β</i>-carboline derivatives, nonocarbolines A−E (<b>1−5</b>). Their structures were elucidated from high-resolution mass spectrometry, 1D and 2D nuclear magnetic resonance spectroscopy, and the absolute configuration of <b>4</b> was determined by using the modified Mosher method. Nonocarboline B (<b>2</b>) displayed moderate antifungal activity against <i>Mucor hiemalis</i>, while nonocarboline D (<b>4</b>) exhibited significant cytotoxic activity against the human lung carcinoma cell line A-549 with the IC<sub>50</sub> value of 1.7 µM. | ||
| 546 | |a EN | ||
| 690 | |a <i>nonomuraea</i> sp. 1808210 cr | ||
| 690 | |a rare actinobacteria | ||
| 690 | |a secondary metabolite | ||
| 690 | |a <i>β</i>-carbolines | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antibiotics, Vol 9, Iss 3, p 126 (2020) | |
| 787 | 0 | |n https://www.mdpi.com/2079-6382/9/3/126 | |
| 787 | 0 | |n https://doaj.org/toc/2079-6382 | |
| 856 | 4 | 1 | |u https://doaj.org/article/31c42cfe7f984c0aa32b7bf0a297e3a1 |z Connect to this object online. |