Protoflavone-Chalcone Hybrids Exhibit Enhanced Antitumor Action through Modulating Redox Balance, Depolarizing the Mitochondrial Membrane, and Inhibiting ATR-Dependent Signaling

• Main Authors: Ahmed Dhahir Latif (Author), Tamás Jernei (Author), Ana Podolski-Renić (Author), Ching-Ying Kuo (Author), Máté Vágvölgyi (Author), Gábor Girst (Author), István Zupkó (Author), Sedef Develi (Author), Engin Ulukaya (Author), Hui-Chun Wang (Author), Milica Pešić (Author), Antal Csámpai (Author), Attila Hunyadi (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hybrid compounds combine fragments with complementary targets to achieve a common pharmacological goal. This approach represents an increasingly popular strategy for drug discovery. In this work, we aimed to design antitumor hybrid compounds based on an inhibitor of ataxia-telangiectasia and Rad3-re...