The Distribution of HLA-system Antigens in Children with Peptic Ulcer
In order to establish the features of HLA-system antigens distribution, their interlocus and intralocus combinations in peptic ulcer in children, all investigated patients (n = 120) and individuals from the control group (n = 100) underwent HLA-typing test of DRB1, DQA1 and DQB1 genes using the meth...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
Zaslavsky O.Yu.,
2015-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | In order to establish the features of HLA-system antigens distribution, their interlocus and intralocus combinations in peptic ulcer in children, all investigated patients (n = 120) and individuals from the control group (n = 100) underwent HLA-typing test of DRB1, DQA1 and DQB1 genes using the method of sequence-specific probe, amplification with sequence-specific primers. Peptic ulcer is associated with the specificities of DRB1*11, DRB1*13, allelic variant DQB1*0401/02, genotype DQB1*0301,0302 and haplotypes DRB1*07/DQA1*0301, DRB1*13/DQA1*0501, DRB1*11/DQB1*0501, DQA1*0102/DQB1*0401/02. Specificity DRB1*15, allele variant DQB1*0201, genotype DQB1*0301,0301 and haplotypes DRB1*15/DQA1*0101, DRB1*15/DQA1*0102, DRB1*01/DQB1*0201, DRB1*15/DQB1*0301, DQA1*0101/DQB1*0201, DQA1*0201/DQB1*0201 determine the resistance to peptic ulcer. |
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| Item Description: | 2224-0551 2307-1168 10.22141/2224-0551.2.1.62.1.2015.83269 |