Paracrine Factors of Stressed Peripheral Blood Mononuclear Cells Activate Proangiogenic and Anti-Proteolytic Processes in Whole Blood Cells and Protect the Endothelial Barrier

• Main Authors: Dragan Copic (Author), Martin Direder (Author), Klaudia Schossleitner (Author), Maria Laggner (Author), Katharina Klas (Author), Daniel Bormann (Author), Hendrik Jan Ankersmit (Author), Michael Mildner (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tissue-regenerative properties have been attributed to secreted paracrine factors derived from stem cells and other cell types. In particular, the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCsec) has been shown to possess high tissue-regenerative and proangiogenic capacities in...