Identification of New <i>N</i>-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors
Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) have been considered target enzymes of depression and neurodegenerative diseases, including Alzheimer's disease (AD). In this study, seventeen <i>N</i>-methyl-piperazine chalcones were synthes...
Saved in:
Main Authors: | Ashraf K. El-Damasy (Author), Jong Eun Park (Author), Hyun Ji Kim (Author), Jinhyuk Lee (Author), Eun-Kyoung Bang (Author), Hoon Kim (Author), Gyochang Keum (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2023-01-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant
by: Ashraf K. El-Damasy, et al.
Published: (2023) -
Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders
by: Payyalot Koyiparambath Vishal, et al.
Published: (2021) -
Identification of Ureidocoumarin-Based Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors via Drug Repurposing Approach, Biological Evaluation, and In Silico Studies
by: Ashraf K. El-Damasy, et al.
Published: (2024) -
Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII
by: Ashraf K. El-Damasy, et al.
Published: (2023) -
Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors
by: Emilio Mateev, et al.
Published: (2023)