Identification of New <i>N</i>-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors

• Main Authors: Ashraf K. El-Damasy (Author), Jong Eun Park (Author), Hyun Ji Kim (Author), Jinhyuk Lee (Author), Eun-Kyoung Bang (Author), Hoon Kim (Author), Gyochang Keum (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) have been considered target enzymes of depression and neurodegenerative diseases, including Alzheimer's disease (AD). In this study, seventeen <i>N</i>-methyl-piperazine chalcones were synthes...