Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway

Considerable attention has been raised on crizotinib- and sunitinib-induced hepatotoxicity, but the underlying mechanisms need further examination. In addition, limited therapeutic strategies exist to reduce the liver damage caused by crizotinib and sunitinib. This study investigated the mechanisms...

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Main Authors: Lin Guo (Author), Hui Gong (Author), Ting-Li Tang (Author), Bi-Kui Zhang (Author), Lei-Yi Zhang (Author), Miao Yan (Author)
Format: Book
Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
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