A Correlation between First-void Morning Urinary Protein to Creatinine Ratio (UPCR) and 24 Hours Urinary Protein in Pregnancy with Suspected Preeclampsia

• Main Authors: Pimchanok Pariyaeksut (Author), Tripop lertbunnaphong (Author), Jarunee Leetheeragul (Author), Dittakarn Boriboonhirunsarn (Author)
• Format: Book
• Published: The Royal Thai College of Obstetricians and Gynaecologists, 2014-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 0857-6084; 0857-6084
• Keywords: preeclampsia; urine protein to creatinine ratio; 24-hour urine protein; Gynecology and obstetrics; RG1-991
• Source: Thai Journal of Obstetrics and Gynaecology, Vol 22, Iss 4, Pp 173-180 (2014)

Objective:To evaluate a correlation between first-void morning urinary protein to creatinine ratio (UPCR) and 24-hour urine protein in pregnant women suspected of preeclampsia.Materials and Methods: A total of 40 pregnant women suspected of preeclampsia were enrolled and admitted for 24-hour urine collection. Collected urine was divided into 2 parts, first-void morning urine and the remaining. First-void morning UPCR was determined and 24-hour urine protein was calculated by a combination of protein from both specimens. Significant proteinuria was diagnosed if the total 24-hour urine protein was greater than 300 mg. A correlation between first-void morning UPCR and 24-hour urine protein was estimated using Pearson product-moment correlation coefficient (r).Results: Mean age was 31.0 ± 7.0 years and mean gestational age was 33.2 ± 4.6 weeks. Eight patients (20%) had significant proteinuria and were diagnosed as preeclampsia. A correlation between first-void morning UPCR and 24-hour urine protein showed a significant positive correlation with coefficient (r) of 0.76, p < 0.001. At the cut-off value of 0.3, first-void morning UPCR had sensitivity of 87.5% (95% CI 46.7 - 99.3) specificity of 96.9% (95% CI 82.0 - 99.8) for diagnosis of significant proteinuria.Conclusions: First-void morning UPCR significantly correlated with 24-hour urine protein. It should be considered as an alternative method for detecting significant proteinuria in women suspected of preeclampsia.