Use of oral cholera vaccine as a vaccine probe to determine the burden of culture-negative cholera.

• Main Authors: Justin Im (Author), Md Taufiqul Islam (Author), Faisal Ahmmed (Author), Deok Ryun Kim (Author), Yun Chon (Author), K Zaman (Author), Ashraful Islam Khan (Author), Mohammad Ali (Author), Florian Marks (Author), Firdausi Qadri (Author), John D Clemens (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Analyses of stool from patients with acute watery diarrhea (AWD) using sensitive molecular diagnostics have challenged whether fecal microbiological cultures have acceptably high sensitivity for cholera diagnosis. If true, these findings imply that current estimates of the global burden of cholera,...