PBPK Modelling of Dexamethasone in Patients With COVID-19 and Liver Disease

• Main Authors: Maiara Camotti Montanha (Author), Nicolas Cottura (Author), Michael Booth (Author), Daryl Hodge (Author), Fazila Bunglawala (Author), Hannah Kinvig (Author), Sandra Grañana-Castillo (Author), Andrew Lloyd (Author), Saye Khoo (Author), Marco Siccardi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the study was to apply Physiologically-Based Pharmacokinetic (PBPK) modelling to predict the effect of liver disease (LD) on the pharmacokinetics (PK) of dexamethasone (DEX) in the treatment of COVID-19. A whole-body PBPK model was created to simulate 100 adult individuals aged 18-60 year...