Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans

• Main Authors: Anna-Maria Ordelheide (Author), Nadja Gommer (Author), Anja Böhm (Author), Carina Hermann (Author), Inga Thielker (Author), Fausto Machicao (Author), Andreas Fritsche (Author), Norbert Stefan (Author), Hans-Ulrich Häring (Author), Harald Staiger (Author)
• Format: Book
• Published: Elsevier, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Circulating long-chain free fatty acids (FFAs) are important metabolic signals that acutely enhance fatty acid oxidation, thermogenesis, energy expenditure, and insulin secretion. However, if chronically elevated, they provoke inflammation, insulin resistance, and β-cell failure. Moreover...