In Vitro Activity of "Old" and "New" Antimicrobials against the <i>Klebsiella pneumoniae</i> Complex
The <i>Klebsiella pneumoniae</i> complex is a commonly isolated bacteria in human infections. These opportunistic pathogens pose a serious threat to public health due to their potential transmission to the human population. Resistance to carbapenems is a significant antimicrobial resista...
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MDPI AG,
2024-01-01T00:00:00Z.
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| Summary: | The <i>Klebsiella pneumoniae</i> complex is a commonly isolated bacteria in human infections. These opportunistic pathogens pose a serious threat to public health due to their potential transmission to the human population. Resistance to carbapenems is a significant antimicrobial resistance mechanism, leading to limited therapeutic options. Therefore, the aim of this study was to evaluate the in vitro activity of fosfomycin, colistin, ceftazidime-avibactam, and meropenem-vaborbactam against multidrug-resistant <i>K. pneumoniae</i> complex strains. This study involved 160 strains of Gram-negative rods, comprising 138 <i>K. pneumoniae</i> and 22 <i>K. variicola</i>. The minimal inhibitory concentration of fosfomycin was estimated using the agar dilution method, and for colistin, the microdilution method was employed. Susceptibility to ceftazidime-avibactam and meropenem-vaborbactam was determined using the gradient strip method. All analyzed <i>K. pneumoniae</i> complex isolates produced extended-spectrum β-lactamases, and 60.0% exhibited carbapenemases. The majority of the analyzed strains were susceptible to fosfomycin and colistin (62.5%). Among pandrug-resistant <i>K. pneumoniae</i> complex isolates, the highest susceptibility was observed with colistin (43.9%). Fosfomycin demonstrated good activity against ESβLs- and VIM-positive isolates from this complex. Colistin also exhibited satisfactory in vitro activity against VIM- and KPC-positive isolates from the <i>K. pneumoniae</i> complex. Ceftazidime-avibactam displayed good activity against <i>K. pneumoniae</i> complex strains producing ESβLs, KPC, and OXA enzymes. Additionally, meropenem-vaborbactam showed satisfactory in vitro activity against ESβLs- and KPC-positive isolates from this complex. |
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| Item Description: | 10.3390/antibiotics13020126 2079-6382 |