Critical appraisal of bilastine for the treatment of allergic rhinoconjunctivitis and urticaria
Belen Sadaba, Jose Ramon Azanza, Almundena Gomez-Guiu, Raquel RodilClinical Pharmacology Service, Clinica Universidad de Navarra, Navarra, SpainAbstract: Bilastine is a second generation antihistamine indicated for the treatment of seasonal or perennial allergic rhinoconjunctivitis and chronic urtic...
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Dove Medical Press,
2013-05-01T00:00:00Z.
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| 100 | 1 | 0 | |a Sadaba B |e author |
| 700 | 1 | 0 | |a Azanza JR |e author |
| 700 | 1 | 0 | |a Gomez-Guiu A |e author |
| 700 | 1 | 0 | |a Rodil R |e author |
| 245 | 0 | 0 | |a Critical appraisal of bilastine for the treatment of allergic rhinoconjunctivitis and urticaria |
| 260 | |b Dove Medical Press, |c 2013-05-01T00:00:00Z. | ||
| 500 | |a 1176-6336 | ||
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| 520 | |a Belen Sadaba, Jose Ramon Azanza, Almundena Gomez-Guiu, Raquel RodilClinical Pharmacology Service, Clinica Universidad de Navarra, Navarra, SpainAbstract: Bilastine is a second generation antihistamine indicated for the treatment of seasonal or perennial allergic rhinoconjunctivitis and chronic urticaria with a daily dose of 20 mg, in adults and children over 12 years of age. The efficacy of bilastine has been shown to be similar to that of the comparator drugs for the control of the nasal and nonnasal symptoms of allergic rhinoconjunctivitis, while also showing a subjective improvement in the quality of life and in overall clinical impression. For chronic urticaria the symptoms (itching and the development of papules) lessens from the second day of treatment onwards, in a similar way to other antihistamines used as comparators. Bilastine should not be administered at meal times to avoid interference with the absorption process. It is not distributed to the central nervous system, is scarcely metabolized, and elimination is through the kidneys and feces, with a 14-hour elimination half-life. It has no effect on cytochrome P450. During clinical development, bilastine was shown to be a drug that is adequately tolerated, with a similar effect to placebo with regard to drowsiness and changes in heart rate. In relation to its use, headaches were the most frequent adverse effect to be reported. No cardiotoxic effects have been observed, and the therapeutic dose does not alter the state of alertness.Keywords: bilastine, allergic rhinoconjunctivitis, chronic urticaria, second generation antihistamine, drowsiness, CYP450 | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Therapeutics and Clinical Risk Management, Vol 2013, Iss default, Pp 197-205 (2013) | |
| 787 | 0 | |n http://www.dovepress.com/critical-appraisal-of-bilastine-for-the-treatment-of-allergic-rhinocon-a12938 | |
| 787 | 0 | |n https://doaj.org/toc/1176-6336 | |
| 787 | 0 | |n https://doaj.org/toc/1178-203X | |
| 856 | 4 | 1 | |u https://doaj.org/article/33caaac70db54ff6912057bf13b781e6 |z Connect to this object online. |