A Review of Vitamin D Deficiency in the Critical Care Population
It is well documented that a large percentage of the general population is either vitamin D insufficient or deficient. Vitamin D deficiency adversely affects bone health. More recently, it has been reported that vitamin D is an important component in immune function and glycemic control Substantial...
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MDPI AG,
2014-01-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_33e676f267e84cc0b1a38d10e883b39d | ||
042 | |a dc | ||
100 | 1 | 0 | |a Kelly Massey |e author |
700 | 1 | 0 | |a Roland N. Dickerson |e author |
700 | 1 | 0 | |a Rex O. Brown |e author |
245 | 0 | 0 | |a A Review of Vitamin D Deficiency in the Critical Care Population |
260 | |b MDPI AG, |c 2014-01-01T00:00:00Z. | ||
500 | |a 2226-4787 | ||
500 | |a 10.3390/pharmacy2010040 | ||
520 | |a It is well documented that a large percentage of the general population is either vitamin D insufficient or deficient. Vitamin D deficiency adversely affects bone health. More recently, it has been reported that vitamin D is an important component in immune function and glycemic control Substantial data exist that demonstrate an association between vitamin D insufficiency/deficiency and mortality/clinical outcomes of critically ill patients. The larger clinical trials addressing this association have demonstrated an increased odds ratio for mortality in both vitamin D insufficient and deficient patients when compared to those with sufficient vitamin D. There is also some evidence that vitamin D status worsens during critical illness without supplementation of this vitamin. Supplementation of vitamin D during critical illness of patients with vitamin D deficiency has been studied, but not in great detail. Daily supplementation of the recommended dietary allowance (RDA) of vitamin D does very little to improve the 25(OH)D serum concentrations in the critically ill patients with vitamin D insufficiency or deficiency. There is some evidence that high-dose therapy of vitamin D improves the depressed serum concentrations of this vitamin; however, there are no clinical outcome data available yet. The association between vitamin D insufficiency or deficiency and clinical outcome in the critically ill appears to be important. Supplementation of vitamin D will increase the serum concentrations of this vitamin; however the optimal dose needs to be identified along with an assessment of clinical outcome. | ||
546 | |a EN | ||
690 | |a vitamin D | ||
690 | |a critical illness | ||
690 | |a ergocalciferol | ||
690 | |a cholecalciferol | ||
690 | |a Pharmacy and materia medica | ||
690 | |a RS1-441 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Pharmacy, Vol 2, Iss 1, Pp 40-49 (2014) | |
787 | 0 | |n http://www.mdpi.com/2226-4787/2/1/40 | |
787 | 0 | |n https://doaj.org/toc/2226-4787 | |
856 | 4 | 1 | |u https://doaj.org/article/33e676f267e84cc0b1a38d10e883b39d |z Connect to this object online. |