A Review of Vitamin D Deficiency in the Critical Care Population

It is well documented that a large percentage of the general population is either vitamin D insufficient or deficient. Vitamin D deficiency adversely affects bone health. More recently, it has been reported that vitamin D is an important component in immune function and glycemic control Substantial...

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Main Authors: Kelly Massey (Author), Roland N. Dickerson (Author), Rex O. Brown (Author)
Format: Book
Published: MDPI AG, 2014-01-01T00:00:00Z.
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100 1 0 |a Kelly Massey  |e author 
700 1 0 |a Roland N. Dickerson  |e author 
700 1 0 |a Rex O. Brown  |e author 
245 0 0 |a A Review of Vitamin D Deficiency in the Critical Care Population 
260 |b MDPI AG,   |c 2014-01-01T00:00:00Z. 
500 |a 2226-4787 
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520 |a It is well documented that a large percentage of the general population is either vitamin D insufficient or deficient. Vitamin D deficiency adversely affects bone health. More recently, it has been reported that vitamin D is an important component in immune function and glycemic control Substantial data exist that demonstrate an association between vitamin D insufficiency/deficiency and mortality/clinical outcomes of critically ill patients. The larger clinical trials addressing this association have demonstrated an increased odds ratio for mortality in both vitamin D insufficient and deficient patients when compared to those with sufficient vitamin D. There is also some evidence that vitamin D status worsens during critical illness without supplementation of this vitamin. Supplementation of vitamin D during critical illness of patients with vitamin D deficiency has been studied, but not in great detail. Daily supplementation of the recommended dietary allowance (RDA) of vitamin D does very little to improve the 25(OH)D serum concentrations in the critically ill patients with vitamin D insufficiency or deficiency. There is some evidence that high-dose therapy of vitamin D improves the depressed serum concentrations of this vitamin; however, there are no clinical outcome data available yet. The association between vitamin D insufficiency or deficiency and clinical outcome in the critically ill appears to be important. Supplementation of vitamin D will increase the serum concentrations of this vitamin; however the optimal dose needs to be identified along with an assessment of clinical outcome. 
546 |a EN 
690 |a vitamin D 
690 |a critical illness 
690 |a ergocalciferol 
690 |a cholecalciferol 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
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786 0 |n Pharmacy, Vol 2, Iss 1, Pp 40-49 (2014) 
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856 4 1 |u https://doaj.org/article/33e676f267e84cc0b1a38d10e883b39d  |z Connect to this object online.