Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs

• Main Authors: Andre A. R. Teixeira (Author), Sara D'Angelo (Author), M. Frank Erasmus (Author), Camila Leal-Lopes (Author), Fortunato Ferrara (Author), Laura P. Spector (Author), Leslie Naranjo (Author), Esteban Molina (Author), Tamara Max (Author), Ashley DeAguero (Author), Katherine Perea (Author), Shaun Stewart (Author), Rebecca A. Buonpane (Author), Horacio G. Nastri (Author), Andrew R. M. Bradbury (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Affinity maturation is often a necessary step for the development of potent therapeutic molecules. Many different diversification strategies have been used for antibody affinity maturation, including error-prone PCR, chain shuffling, and targeted complementary-determining region (CDR) mutation. Alth...