An Efficient Disinfectant, Composite Material {SLS@[Zn₃(CitH)₂]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens

• Main Authors: V.A. Karetsi (Author), C.N. Banti (Author), N. Kourkoumelis (Author), C. Papachristodoulou (Author), C.D. Stalikas (Author), C.P. Raptopoulou (Author), V. Psycharis (Author), P. Zoumpoulakis (Author), T. Mavromoustakos (Author), I. Sainis (Author), S.K. Hadjikakou (Author)
• Format: Book
• Published: MDPI AG, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

The [Zn₃(CitH)₂] (<b>1</b>) (CitH₄= citric acid), was dispersed in sodium lauryl sulphate (SLS) to form the micelle of SLS@[Zn₃(CitH)₂] (<b>2</b>). This material <b>2</b> was incorporated in hydrogel made by hydroxyethyl-methacrylate (HEMA), an ingredient of contact lenses, toward the formation of pHEMA@(SLS@[Zn₃(CitH)₂]) (<b>3</b>). Samples of <b>1</b> and <b>2</b> were characterized by UV-Vis, ¹H-NMR, FT-IR, FT-Raman, single crystal X-ray crystallography, X-ray fluorescence analysis, atomic absorption and TG/DTA/DSC. The antibacterial activity of <b>1</b>&#8722;<b>3</b> as well as of SLS against Gram-positive <i>(Staphylococcus epidermidis (St. epidermidis)</i> and <i>Staphylococcus aureus (St. aureus))</i> and Gram-negative <i>(Pseudomonas aeruginosa (PAO1)</i>, and <i>Escherichia coli (E. coli))</i> bacteria was evaluated by the means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibitory zone (IZ). <b>2</b> showed 10 to 20-fold higher activity than <b>1</b> against the bacteria tested. Moreover the <b>3</b> decreases the abundance of Gram-positive microbes up to 30% (<i>St. aureus</i>) and up to 20% (PAO1) the Gram-negative ones. The noteworthy antimicrobial activity of the obtained composite <b>3</b> suggests an effective antimicrobial additive for infection-free contact lenses.

Item Description

2079-6382
10.3390/antibiotics8040213