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Structure-Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors

To evaluate the differences in action of commercially available 2-oxoglutarate mimetics and "branched-tail" oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF PHD), the inhibitors' IC<sub>50</sub> values in the activation of HIF1 ODD-luciferase rep...

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Main Authors: Andrey A. Poloznikov (Author), Sergey V. Nikulin (Author), Dmitry M. Hushpulian (Author), Anna Yu. Khristichenko (Author), Andrey I. Osipyants (Author), Andrey F. Asachenko (Author), Olga V. Shurupova (Author), Svyatoslav S. Savin (Author), Sue H. Lee (Author), Irina N. Gaisina (Author), Gregory R. J. Thatcher (Author), Anthony Narciso (Author), Eric P. Chang (Author), Sergey V. Kazakov (Author), Nancy Krucher (Author), Vladimir I. Tishkov (Author), Bobby Thomas (Author), Irina G. Gazaryan (Author)
Format: Book
Published: MDPI AG, 2022-01-01T00:00:00Z.
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