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Antibacterial, Trichomonacidal, and Cytotoxic Activities of <i>Pleopeltis crassinervata</i> Extracts

<i>Pleopeltis crassinervata</i> is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this p...

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Main Authors: Jhony Anacleto-Santos (Author), Elisa Vega-Ávila (Author), Leticia Pacheco (Author), Manuel Lacueva-Arnedo (Author), Alicia Gómez-Barrio (Author), Alexandra Ibáñez-Escribano (Author), Teresa de Jesús López-Pérez (Author), Brenda Casarrubias-Tabarez (Author), Fernando Calzada (Author), Perla Yolanda López-Camacho (Author), Norma Rivera-Fernández (Author)
Format: Book
Published: MDPI AG, 2024-05-01T00:00:00Z.
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Summary:<i>Pleopeltis crassinervata</i> is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this plant within the context of traditional medicine. In the present study, we investigated the biological activity of extracts and fractions obtained from <i>P. crassinervata</i> organs against bacteria (<i>Salmonella typhimurium</i>, <i>Salmonella typhi</i>, <i>Staphylococcus aureus</i>, <i>Proteus mirabilis</i>, <i>Shigella flexneri</i>, <i>Bacillus subtilis</i>, <i>Escherichia coli)</i> and <i>Trichomonas vaginalis</i> using in vitro models. The precipitate fraction obtained from the frond methanolic extract showed significant antibacterial activity (minimal inhibitory concentration [MIC] 120 µg/mL) against the <i>Staphylococcus aureus</i> strain and was effective against both Gram-positive and Gram-negative bacteria. The hexane fraction also obtained from frond methanolic extract, showed a trichomonacidal effect with an IC<sub>50</sub> of 82.8 μg/mL and a low cytotoxic effect. Hsf6 exhibited the highest activity against <i>T. vaginalis</i>, and the GC-MS analysis revealed that the predominant compound was 16-pregnenolone. The remaining identified compounds were primarily terpene-type compounds.
Item Description:10.3390/pharmaceutics16050624
1999-4923

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