Coumarin Derivatives Exert Anti-Lung Cancer Activity by Inhibition of Epithelial-Mesenchymal Transition and Migration in A549 Cells

• Main Authors: Rodrigo Santos Aquino de Araújo (Author), Julianderson de Oliveira dos Santos Carmo (Author), Simone Lara de Omena Silva (Author), Camila Radelley Azevedo Costa da Silva (Author), Tayhana Priscila Medeiros Souza (Author), Natália Barbosa de Mélo (Author), Jean-Jacques Bourguignon (Author), Martine Schmitt (Author), Thiago Mendonça de Aquino (Author), Renato Santos Rodarte (Author), Ricardo Olímpio de Moura (Author), José Maria Barbosa Filho (Author), Emiliano Barreto (Author), Francisco Jaime Bezerra Mendonça-Junior (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of coumarin derivatives and isosteres were synthesized from the reaction of triflic intermediates with phenylboronic acids, terminal alkynes, and organozinc compounds through <i>palladium</i>-catalyzed cross-coupling reactions. The in vitro cytotoxic effect of the compounds was...