Altered vitamin A metabolism in human liver slices corresponds to fibrogenesis

• Main Authors: Lindsay C. Czuba (Author), Xia Wu (Author), Weize Huang (Author), Nicole Hollingshead (Author), Jessica B. Roberto (Author), Heidi L. Kenerson (Author), Raymond S. Yeung (Author), Ian N. Crispe (Author), Nina Isoherranen (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract All‐trans‐retinoic acid (atRA), the active metabolite of vitamin A, has antifibrogenic properties in vitro and in animal models. Liver vitamin A homeostasis is maintained by cell‐specific enzymatic activities including storage in hepatic stellate cells (HSCs), secretion into circulation fro...