Burning Mouth Syndrome (BMS)-Treatment with Verbal and Written Information, B Vitamins, Probiotics, and Low-Level Laser Therapy: A Randomized Clinical Trial

Background: The objective of this study was to determine the most effective treatment option for burning mouth syndrome. Methods: Informative treatment alone, B vitamin injections, oral cavity probiotics, and low-level laser therapy were evaluated and compared. The study included new patients diagno...

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Main Authors: Božana Lončar-Brzak (Author), Ivana Škrinjar (Author), Vlaho Brailo (Author), Danica Vidović-Juras (Author), Lada Šumilin (Author), Ana Andabak-Rogulj (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Božana Lončar-Brzak  |e author 
700 1 0 |a Ivana Škrinjar  |e author 
700 1 0 |a Vlaho Brailo  |e author 
700 1 0 |a Danica Vidović-Juras  |e author 
700 1 0 |a Lada Šumilin  |e author 
700 1 0 |a Ana Andabak-Rogulj  |e author 
245 0 0 |a Burning Mouth Syndrome (BMS)-Treatment with Verbal and Written Information, B Vitamins, Probiotics, and Low-Level Laser Therapy: A Randomized Clinical Trial 
260 |b MDPI AG,   |c 2022-03-01T00:00:00Z. 
500 |a 10.3390/dj10030044 
500 |a 2304-6767 
520 |a Background: The objective of this study was to determine the most effective treatment option for burning mouth syndrome. Methods: Informative treatment alone, B vitamin injections, oral cavity probiotics, and low-level laser therapy were evaluated and compared. The study included new patients diagnosed with burning mouth syndrome, who were randomly allocated into one of four treatment groups. The primary outcome was improvement in patient's quality of life as determined by a self-perceived Oral Health Impact Profile-14 (OHIP-14) quality of life questionnaire before and after therapy. The secondary outcome was determination of mucosal symptom intensity according to visual analog scale (VAS) grading from 0 to 10. Data were submitted to statistical analysis. Results: A total of 62 patients completed the study. Oral cavity probiotics and LLLT scores for OHIP-14 resulted in a statistically significant difference before and after therapy. Standardized effect sizes between OHIP scores before and after treatment were the greatest for patients who had received oral cavity probiotics. Conclusions: Oral cavity probiotics and LLLT were the most effective treatment for improvement in quality of life. Further investigation on a larger group of patients is required. 
546 |a EN 
690 |a burning mouth syndrome 
690 |a low-level laser therapy 
690 |a B vitamins 
690 |a probiotics 
690 |a oral health impact profile 
690 |a visual analogue scale 
690 |a Dentistry 
690 |a RK1-715 
655 7 |a article  |2 local 
786 0 |n Dentistry Journal, Vol 10, Iss 3, p 44 (2022) 
787 0 |n https://www.mdpi.com/2304-6767/10/3/44 
787 0 |n https://doaj.org/toc/2304-6767 
856 4 1 |u https://doaj.org/article/352efb9a48de4bc3b9a79e16d95788d6  |z Connect to this object online.