Integrative chemogenomic analysis identifies small molecules that partially rescue ΔF508‐CFTR for cystic fibrosis
Abstract Rare diseases affect 10% of the first‐world population, yet over 95% lack even a single pharmaceutical treatment. In the present age of information, we need ways to leverage our vast data and knowledge to streamline therapeutic development and lessen this gap. Here, we develop and implement...
Gardado en:
Main Authors: | Rachel A. Hodos (Author), Matthew D. Strub (Author), Shyam Ramachandran (Author), Ella A. Meleshkevitch (Author), Dmitri Y. Boudko (Author), Robert J. Bridges (Author), Joel T. Dudley (Author), Paul B. McCray Jr (Author) |
---|---|
Formato: | Libro |
Publicado: |
Wiley,
2021-05-01T00:00:00Z.
|
Subjects: | |
Acceso en liña: | Connect to this object online. |
Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|
Títulos similares
-
Analysis of multiple gene co-expression networks to discover interactions favoring CFTR biogenesis and ΔF508-CFTR rescue
por: Matthew D. Strub, et al.
Publicado: (2021) -
Translating in vitro CFTR rescue into small molecule correctors for cystic fibrosis using the Library of Integrated Network‐based Cellular Signatures drug discovery platform
por: Matthew D. Strub, et al.
Publicado: (2022) -
Functional rescue of F508del-CFTR using small molecule correctors
por: Steven eMolinski, et al.
Publicado: (2012) -
Decreasing Poly(ADP-ribose) Polymerase activity restores ΔF508 CFTR trafficking
por: Suzana Maria Anjos, et al.
Publicado: (2012) -
Differential Effects of Oleuropein and Hydroxytyrosol on Aggregation and Stability of CFTR NBD1-ΔF508 Domain
por: Christopher S. Robinson, et al.
Publicado: (2021)