A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

• Main Authors: Ashlee J. Conway (Author), Fiona C. Brown (Author), Robert O. Fullinfaw (Author), Benjamin T. Kile (Author), Stephen M. Jane (Author), David J. Curtis (Author)
• Format: Book
• Published: The Company of Biologists, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A genome-wide ethyl-N-nitrosourea (ENU) mutagenesis screen in mice was performed to identify novel regulators of erythropoiesis. Here, we describe a mouse line, RBC16, which harbours a dominantly inherited mutation in the Cpox gene, responsible for production of the haem biosynthesis enzyme, copropo...