Cover Image

Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo

Abstract Background Polyphyllin VII (PP7), a steroidal saponin from P. polyphylla has been found to exert strong anticancer activity. Little is known about the anti-angiogenesis and anti-metastasis properties of PP7. In this study, the anti-angiogenic and anti-metastatic effects of PP7 on HCC and th...

Full description

Saved in:

Bibliographic Details
Main Authors:	Chao Zhang (Author), Qingrui Li (Author), Guozheng Qin (Author), Yi Zhang (Author), Chaoying Li (Author), Liwen Han (Author), Rongchun Wang (Author), Shudan Wang (Author), Haixia Chen (Author), Kechun Liu (Author), Chengwei He (Author)
Format:	Book
Published:	BMC, 2021-05-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Polyphyllin I exerts anti-hepatocellular carcinoma activity by targeting ZBTB16 to activate the PPARγ/RXRα signaling pathway
by: Lu shan, et al.
Published: (2024)

MiR-124-3p mediates gastric cancer cell ferroptosis induced by an anti-cancer drug polyphyllin I
by: Fang Zheng, et al.
Published: (2023)

Dandelion Polysaccharide Exerts Anti-Angiogenesis Effect on Hepatocellular Carcinoma by Regulating VEGF/HIF-1α Expression
by: Feng Ren, et al.
Published: (2020)

HGFK1 Enhances the Anti-Tumor Effects of Angiogenesis Inhibitors via Inhibition of CD90+ CSCs in Hepatocellular Carcinoma
by: Tao Li, et al.
Published: (2024)

Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer
by: Honggang Wang, et al.
Published: (2017)

Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
by: Fang Zheng, et al.
Published: (2023)

Polyphyllin II suppresses cell migration, invasion, and metastasis by inducing cytoskeletal rearrangement through the ROCK1/LIMK/CFL1 pathway in bladder cancer cells
by: Zhiyong Liu, et al.
Published: (2024)

Corrigendum: Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
by: Fang Zheng, et al.
Published: (2023)

Datura innoxia anti-angiogenesis properties
by: B. Khoshkhoo, et al.
Published: (2017)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
by: Yuan YL, et al.
Published: (2019)

Evaluation of the Developmental Toxicity Induced by E804 in Zebrafish Embryos
by: Rongchun Wang, et al.
Published: (2020)

ANGIOGENESIS INHIBITORS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA
by: Massimiliano Berretta, et al.
Published: (2016)

Angiogenesis in liver cirrhosis and hepatocellular carcinoma
by: Amarapurkar Anjali, et al.
Published: (2008)

The Role of Interleukin 17 in Tumour Proliferation, Angiogenesis, and Metastasis
by: Bob Yang, et al.
Published: (2014)

The role of long non-coding RNAs in angiogenesis and anti-angiogenic therapy resistance in cancer
by: Junxia Liu, et al.
Published: (2022)

Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein
by: Yuying Zhu, et al.
Published: (2020)

Targeting OPA1-Mediated Mitochondrial Fusion Contributed to Celastrol's Anti-Tumor Angiogenesis Effect
by: Gaofu Li, et al.
Published: (2022)

Hepatocellular Carcinoma cells: activity of Amygdalin and Sorafenib in Targeting AMPK /mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death
by: Tarek El-Sewedy, et al.
Published: (2023)

Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway
by: Yuhan Jiao, et al.
Published: (2022)

miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3
by: Chunjing Wang, et al.
Published: (2022)

Anti-Inflammatory and Anti-Angiogenesis Effects of Verapamil on Rat Air Pouch Inflammation Model
by: Tahereh Eteraf-Oskouei, et al.
Published: (2017)

Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis
by: Ana Damjanovic Damjanovic, et al.
Published: (2016)

Endometriosis-Associated Angiogenesis and Anti-angiogenic Therapy for Endometriosis
by: Monica S. Chung, et al.
Published: (2022)

Anti-Angiogenesis Maintenance Therapy in Newly Diagnosed and Relapsed Ovarian Cancer: A Meta-analysis of Phase III Randomized Controlled Trials
by: Yizi Wang, et al.
Published: (2021)

Anti-Tumor Effects of Carrimycin and Monomeric Isovalerylspiramycin I on Hepatocellular Carcinoma in Vitro and in Vivo
by: Yong Jin, et al.
Published: (2021)

Mechanistic Study of Bakuchiol-Induced Anti-breast Cancer Stem Cell and in Vivo Anti-metastasis Effects
by: Li Li, et al.
Published: (2017)

Promoting Angiogenesis Effect and Molecular Mechanism of Isopropyl Caffeate (KYZ), a Novel Metabolism-Derived Candidate Drug, Based on Integrated Network Pharmacology and Transgenic Zebrafish Models
by: Haotian Kong, et al.
Published: (2022)

The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway
by: Zhiqi Li, et al.
Published: (2023)

Probe substrates assay estimates the effect of polyphyllin H on the activity of cytochrome P450 enzymes in human liver microsomes
by: Erhao Wang, et al.
Published: (2024)

Progress and Challenges of Anti-VEGF Agents and Their Sustained-Release Strategies for Retinal Angiogenesis
by: Xu M, et al.
Published: (2022)

Comprehensive investigation of HBV-related hepatocellular carcinoma and choice of anti-HBV therapy
by: Huihui Lu, et al.
Published: (2021)

Extract of Marsdenia tenacissima (Roxb.) Moon [Apocynaceae] Suppresses Hepatocellular Carcinoma by Inhibiting Angiogenesis
by: Yating Pan, et al.
Published: (2022)

Angiogenesis and Metastasis with a Therapeutic Approach: A Review
by: Dariush Rostami, et al.
Published: (2019)

Homoharringtonine Exerts Anti-tumor Effects in Hepatocellular Carcinoma Through Activation of the Hippo Pathway
by: Haina Wang, et al.
Published: (2021)

Metabolic Reprogramming of Sulfur in Hepatocellular Carcinoma and Sulfane Sulfur-Triggered Anti-Cancer Strategy
by: Ximing Zhang, et al.
Published: (2020)

Cancer-speciﬁc calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy
by: Dan Li, et al.
Published: (2021)

Editorial: Novel anti-cancer agents targeting tumour metastasis and stemness
by: Luping Pang, et al.
Published: (2024)

Comprehensive Treatment of Trans-Arterial Chemoembolization Plus Lenvatinib Followed by Camrelizumab for Advanced Hepatocellular Carcinoma Patients
by: Juanfang Liu, et al.
Published: (2021)

Polyphyllin I alleviates neuroinflammation after cerebral ischemia-reperfusion injury via facilitating autophagy-mediated M2 microglial polarization
by: Chunyang Kang, et al.
Published: (2024)

VEGFR2-targeted antibody fused with IFNαmut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity
by: Pengzhao Shang, et al.
Published: (2021)