Vaccination against autoimmune diseases moves closer to the clinic
Biologicals, e.g. TNF inhibitors, have improved dramatically the efficacy of medical interventions in autoimmune diseases, such as in rheumatoid arthritis (RA). However, although progressive inflammation can be halted in this way, no drug-free remissions or lasting cures are reached. For this to bec...
সংরক্ষণ করুন:
| প্রধান লেখক: | |
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| বিন্যাস: | গ্রন্থ |
| প্রকাশিত: |
Taylor & Francis Group,
2020-02-01T00:00:00Z.
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| অনলাইন ব্যবহার করুন: | Connect to this object online. |
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ট্যাগ যুক্ত করুন
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| সংক্ষিপ্ত: | Biologicals, e.g. TNF inhibitors, have improved dramatically the efficacy of medical interventions in autoimmune diseases, such as in rheumatoid arthritis (RA). However, although progressive inflammation can be halted in this way, no drug-free remissions or lasting cures are reached. For this to become real, therapies based on induction antigen-specific immune tolerance are sought. This review describes mechanisms of tolerance and the current possibilities for induction of therapeutic tolerance through antigen-specific vaccination approaches. And despite the fact that for various diseases the search for appropriate autoantigens is ongoing, pioneering studies are now already developed that use more broadly inflammation associated antigens. Through their capacity to preferentially induce regulatory T cells, heat shock proteins are an attractive source of such broadly inflammation associated antigens. |
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| উপাদানের বিবরণ: | 2164-5515 2164-554X 10.1080/21645515.2019.1593085 |