Study of anticonvulsant activity of Valeriana officinalis roots and rhizomes hydroalcoholic extract in mice and relation to nitric oxide

The anticonvulsant effect of Valeriana officinalis roots and rhizomes hydroalcoholic extract was studied, utilizing maximal electroshock (MES) and pentylenetetrazole (PTZ) tests. In the PTZ test, the extract (0.3-3 g/kg, ip) increased the onset time of Tonic Hind Limb Extension dose-dependently. In...

Full description

Saved in:
Bibliographic Details
Main Authors: GH Karimi (Author), H Hosseinzadeh (Author), H Bakhtiyari (Author)
Format: Book
Published: Institue of Medicinal Plants, ACECR, 2003-09-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The anticonvulsant effect of Valeriana officinalis roots and rhizomes hydroalcoholic extract was studied, utilizing maximal electroshock (MES) and pentylenetetrazole (PTZ) tests. In the PTZ test, the extract (0.3-3 g/kg, ip) increased the onset time of Tonic Hind Limb Extension dose-dependently. In the MES test, neither of doses showed antiseizure activity. L-NAME (1-10 mg/kg ip) reduced the anticonvulsant effect of extract in the PTZ test. The results suggest that Valeriana officinalis extract could be a candidate for treatment of petitmal seizure and nitric oxide may be involved in this effect.
Item Description:2717-204X
2717-2058