NOD2-associated granulomatous autoinflammatory syndromes - a short update for clinicians

• Ngā kaituhi matua: Laura Damian (Author), Mihaela Sparchez (Author), Mihaela Lupse (Author), Ioana Felea (Author), Simona Rednic (Author), Cristina Pamfil (Author), Camelia Bucsa (Author), Romana Vulturar (Author)
• Hōputu: Pukapuka
• I whakaputaina: Amaltea Medical Publishing House, 2021-09-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

NOD2 (nucleotide-binding oligomerization domain-2), a pattern recognition receptor, is involved in innate immune defense against pathogens, intestinal mucosal barrier integrity, gut microbiota composition, autophagy, immune homeostasis and inflammation. NOD2 mutations have been associated primarily...