Identification of a Novel Inhibitor of TfR1 from Designed and Synthesized Muriceidine A Derivatives

• Main Authors: Yu Wu (Author), Zongchen Ma (Author), Xiaoyuan Mai (Author), Xiaoling Liu (Author), Pinglin Li (Author), Xin Qi (Author), Guoqiang Li (Author), Jing Li (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. TfR1 is often reported to be overexpressed in malignant cells, and this increase may be associated with poor prognosis in different types of cancer, which makes it an attractive tar...