Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL, and interleukin-12

• Main Authors: Najla Altwaijry (Author), Sukrut Somani (Author), John A. Parkinson (Author), Rothwelle J. Tate (Author), Patricia Keating (Author), Monika Warzecha (Author), Graeme R. Mackenzie (Author), Hing Y. Leung (Author), Christine Dufès (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The possibility of using gene therapy for the treatment of prostate cancer is limited by the lack of intravenously administered delivery systems able to safely and selectively deliver therapeutic genes to tumors. Given that lactoferrin (Lf) receptors are overexpressed on prostate cancer cells, we hy...