Robotic microfluidic imaging of blood stimulation- towards high-throughput portable measurement of haemostasis
Measuring blood and platelet function is vital for the development and use of drugs that combat cardiovascular disease, such as anti-platelet drugs and other medicines that reduce the risk of thrombosis. We propose combining mass-produced microfluidic devices with open-source robotic instrumentation...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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University of Huddersfield Press,
2023-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Measuring blood and platelet function is vital for the development and use of drugs that combat cardiovascular disease, such as anti-platelet drugs and other medicines that reduce the risk of thrombosis. We propose combining mass-produced microfluidic devices with open-source robotic instrumentation to enable development of affordable and portable, yet high-throughput and high-performance haematological testing. A time- and distance-resolved fluid flow analysis by Raspberry Pi imaging integrated with controlled sample addition and illumination, enables simultaneous tracking of capillary rise in 120 individual capillaries within 5 minutes. We showed that time-resolved microcapillary rise imaging permits blood function measurement by measuring thrombin-triggered activation of global haemostasis. Thrombin stimulation slowed vertical fluid velocity, consistent with a dynamic increase in viscosity. Microfluidic systems expand haematological testing towards high-efficiency, multi-parameter blood analysis necessary for understanding and improving cardiovascular health. |
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| Item Description: | 10.5920/bjpharm.1365 2058-8356 |