Robotic microfluidic imaging of blood stimulation- towards high-throughput portable measurement of haemostasis
Measuring blood and platelet function is vital for the development and use of drugs that combat cardiovascular disease, such as anti-platelet drugs and other medicines that reduce the risk of thrombosis. We propose combining mass-produced microfluidic devices with open-source robotic instrumentation...
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| Formato: | Livro |
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University of Huddersfield Press,
2023-12-01T00:00:00Z.
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| Acesso em linha: | Connect to this object online. |
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| 001 | doaj_37b410b3ddce45d2a7035a9e12d4f1ba | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Rüya Meltem Sarıyer |e author |
| 700 | 1 | 0 | |a Kirandeep Gill |e author |
| 700 | 1 | 0 | |a Sarah Helen Needs |e author |
| 700 | 1 | 0 | |a Daniel Hodge |e author |
| 700 | 1 | 0 | |a Nuno M. Reis |e author |
| 700 | 1 | 0 | |a Chris Ian Jones |e author |
| 700 | 1 | 0 | |a Alexander Daniel Edwards |e author |
| 245 | 0 | 0 | |a Robotic microfluidic imaging of blood stimulation- towards high-throughput portable measurement of haemostasis |
| 260 | |b University of Huddersfield Press, |c 2023-12-01T00:00:00Z. | ||
| 500 | |a 10.5920/bjpharm.1365 | ||
| 500 | |a 2058-8356 | ||
| 520 | |a Measuring blood and platelet function is vital for the development and use of drugs that combat cardiovascular disease, such as anti-platelet drugs and other medicines that reduce the risk of thrombosis. We propose combining mass-produced microfluidic devices with open-source robotic instrumentation to enable development of affordable and portable, yet high-throughput and high-performance haematological testing. A time- and distance-resolved fluid flow analysis by Raspberry Pi imaging integrated with controlled sample addition and illumination, enables simultaneous tracking of capillary rise in 120 individual capillaries within 5 minutes. We showed that time-resolved microcapillary rise imaging permits blood function measurement by measuring thrombin-triggered activation of global haemostasis. Thrombin stimulation slowed vertical fluid velocity, consistent with a dynamic increase in viscosity. Microfluidic systems expand haematological testing towards high-efficiency, multi-parameter blood analysis necessary for understanding and improving cardiovascular health. | ||
| 546 | |a EN | ||
| 690 | |a microfluidics | ||
| 690 | |a haemostasis | ||
| 690 | |a raspberry pi | ||
| 690 | |a blood analysis | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n British Journal of Pharmacy, Vol 8, Iss 2 (2023) | |
| 787 | 0 | |n https://www.bjpharm.org.uk/article/1365/galley/1014/view/ | |
| 787 | 0 | |n https://doaj.org/toc/2058-8356 | |
| 856 | 4 | 1 | |u https://doaj.org/article/37b410b3ddce45d2a7035a9e12d4f1ba |z Connect to this object online. |