DNA damage response and repair gene mutations are associated with tumor mutational burden and outcomes to platinum-based chemotherapy/immunotherapy in advanced NSCLC patients

• Autori principali: Weiguang Gu (Autore), Wenya Zhuang (Autore), Mengxia Zhuang (Autore), Minhong He (Autore), Zhihua Li (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2023-11-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background DNA damage response and repair (DDR) genes are crucial for maintaining the integrity of the genome. This study aims to explore the correlation of DDR gene mutations with TMB, clinical characteristics, and outcomes to platinum-based chemotherapy and platinum-based chemotherapy/imm...