<i>Armillaria mellea</i> Mycelia Alleviate PM2.5-Induced Pulmonary Inflammation in Murine Models

• Main Authors: Yi-Ping Huang (Author), Yu-Tsen Huang (Author), Hui-Yu Wu (Author), Li-Fang Chou (Author), You-Shan Tsai (Author), Yih-Min Jiang (Author), Wan-Ping Chen (Author), Ting-Wei Lin (Author), Chin-Chu Chen (Author), Chih-Ho Lai (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Particulate matter (PM) with an aerodynamic diameter of ≤2.5 μm (PM2.5) significantly contributes to various disease-related respiratory inflammations. <i>Armillaria mellea</i>, recognized for its medicinal properties, could alleviate these respiratory ailments. However, its efficacy against PM2.5-induced inflammation remains elusive. In this study, we investigated whether <i>A. mellea</i> mycelia could mitigate PM2.5-induced respiratory inflammation and assessed the underlying mechanisms. Our results showed that <i>A. mellea</i> mycelia significantly reduced PM2.5-induced nitric oxide (NO) production and nuclear factor (NF)-κB activation in macrophages. Furthermore, <i>A. mellea</i> mycelia suppressed the expression of inflammatory mediators, indicating their potent antioxidant and anti-inflammatory properties. In murine models, <i>A. mellea</i> mycelia mitigated PM2.5-induced lung inflammation and cytokine secretion, restoring lung inflammatory status. Our results highlight the potential of <i>A. mellea</i> mycelia to treat PM2.5-induced respiratory inflammation. The antioxidant and anti-inflammatory effects of <i>A. mellea</i> mycelia demonstrated in vitro and in vivo hold promising potential for developing respiratory health improvement interventions upon PM2.5 exposure.

Item Description

10.3390/antiox13111381
2076-3921