Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice
We investigated whether the descending noradrenergic system regulates allergic itch. Mosquito allergy of the hind paw elicited biting, an itch-related response, in sensitized mice. The biting was inhibited by intrathecal clonidine and reversed by yohimbine, an α2-adrenoceptor antagonist. The biting...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2011-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_37d653552b3f4f29adf84b2e13f3d5a8 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yoshikazu Gotoh |e author |
| 700 | 1 | 0 | |a Yu Omori |e author |
| 700 | 1 | 0 | |a Tsugunobu Andoh |e author |
| 700 | 1 | 0 | |a Yasushi Kuraishi |e author |
| 245 | 0 | 0 | |a Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice |
| 260 | |b Elsevier, |c 2011-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.10305SC | ||
| 520 | |a We investigated whether the descending noradrenergic system regulates allergic itch. Mosquito allergy of the hind paw elicited biting, an itch-related response, in sensitized mice. The biting was inhibited by intrathecal clonidine and reversed by yohimbine, an α2-adrenoceptor antagonist. The biting was increased by intrathecal pretreatment with the catecholaminergic neurotoxin 6-hydroxydopamine and the α-adrenoceptor antagonist phentolamine but not the serotonergic neurotoxin 5,7-dihydroxytryptamine. We propose that α2-adrenoceptors are involved in the inhibition of allergic itch in the spinal cord and that the descending noradrenergic system exerts a tonic inhibition on the itch signaling. The serotonergic system may not be involved. Keywords:: allergic itch, clonidine, descending noradrenergic system | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 115, Iss 3, Pp 417-420 (2011) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319307716 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/37d653552b3f4f29adf84b2e13f3d5a8 |z Connect to this object online. |