Prevalence of gastrointestinal pathogens in Sub-Saharan Africa: systematic review and meta-analysis

A significant proportion of vulnerable people in sub-Saharan Africa (SSA) remain at risk for contracting diarrhoeal diseases due to the presence of many risk factors facilitating their transmission. A systematic review of published articles from the SSA region was done to determine the prevalence an...

Full description

Saved in:
Bibliographic Details
Main Authors: Stephanie M. Fletcher (Author), Damien Stark (Author), John Ellis (Author)
Format: Book
Published: AOSIS, 2011-09-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

MARC

LEADER 00000 am a22000003u 4500
001 doaj_37f6e85b7b8d4ea5a3a1ae85e773525a
042 |a dc 
100 1 0 |a Stephanie M. Fletcher  |e author 
700 1 0 |a Damien Stark  |e author 
700 1 0 |a John Ellis  |e author 
245 0 0 |a Prevalence of gastrointestinal pathogens in Sub-Saharan Africa: systematic review and meta-analysis 
260 |b AOSIS,   |c 2011-09-01T00:00:00Z. 
500 |a 10.4081/jphia.2011.e30 
500 |a 2038-9922 
500 |a 2038-9930 
520 |a A significant proportion of vulnerable people in sub-Saharan Africa (SSA) remain at risk for contracting diarrhoeal diseases due to the presence of many risk factors facilitating their transmission. A systematic review of published articles from the SSA region was done to determine the prevalence and types of diarrhoeal pathogens in circulation, based on a search of databases, including EBSCO host, PubMed, Scopus, Science Direct, Google scholar and Web of Science was done between September 2009 and December 2010. Data were summarized from 27 studies, with pooled data analysed and reported. Pathogens were isolated from between 26.8-65.6% of cases, with an overall isolation rate of 55.7% (95% CI, 48.2-62.9%). Isolation rates were highest amongst adult cases followed by children, and the odds of isolating a pathogen was greater in diarrhoeal cases (Odds Ratio 4.93 (95% CI, 1.99 to 12.23), than in asymptomatic controls. Overall isolation ranged from 8% to 99%; and heterogeneity testing suggests differences between age groups (Q=5.806; df=2, P=0. 055). Mixed E. coli spp., (29.95%), Cryptosporidium (21.52%), Cyclospora (18%), Entamoeba, (13.8%), Shigella spp. (10.49%), Salmonella spp. (8.36%), and Campylobacter spp. (8.33%), were most commonly reported, and rotavirus was the most common virus isolated. This is the first review to look at the range of enteric pathogens circulating in SSA, and has confirmed high rates of isolation of pathogens from diarrhoeal cases. Public health practitioners can use this information to understanding the challenges related to diarrhoeal illness and set priorities for their prevention and control. 
546 |a EN 
690 |a Enteric pathogens 
690 |a diarrhoea 
690 |a gastrointestinal infections 
690 |a Sub-Saharan Africa 
690 |a environmental health. 
690 |a Public aspects of medicine 
690 |a RA1-1270 
655 7 |a article  |2 local 
786 0 |n Journal of Public Health in Africa, Vol 2, Iss 2 (2011) 
787 0 |n http://www.publichealthinafrica.org/index.php/jphia/article/view/95 
787 0 |n https://doaj.org/toc/2038-9922 
787 0 |n https://doaj.org/toc/2038-9930 
856 4 1 |u https://doaj.org/article/37f6e85b7b8d4ea5a3a1ae85e773525a  |z Connect to this object online.