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Translational and pharmacokinetic‐pharmacodynamic application for the clinical development of GDC‐0334, a novel TRPA1 inhibitor

Abstract GDC‐0334 is a novel small molecule inhibitor of transient receptor potential cation channel member A1 (TRPA1), a promising therapeutic target for many nervous system and respiratory diseases. The pharmacokinetic (PK) profile and pharmacodynamic (PD) effects of GDC‐0334 were evaluated in thi...

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Main Authors: Phyllis Chan (Author), Han Ting Ding (Author), Bianca M. Liederer (Author), Jialin Mao (Author), Paula Belloni (Author), Liuxi Chen (Author), Simon S. Gao (Author), Victory Joseph (Author), Xiaoying Yang (Author), Joseph S. Lin (Author), Mayur S. Mitra (Author), Wendy S. Putnam (Author), Angelica Quartino (Author), Rebecca N. Bauer (Author), Lin Pan (Author)
Format: Book
Published: Wiley, 2021-09-01T00:00:00Z.
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