The Investigation of Flory-Huggins Interaction Parameters for Amorphous Solid Dispersion Across the Entire Temperature and Composition Range

• Main Authors: Yiwei Tian (Author), Kaijie Qian (Author), Esther Jacobs (Author), Esther Amstad (Author), David S. Jones (Author), Lorenzo Stella (Author), Gavin P. Andrews (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amorphous solid dispersion (ASD) is one of the most promising enabling formulations featuring significant water solubility and bioavailability enhancements for biopharmaceutical classification system (BCS) class II and IV drugs. An accurate thermodynamic understanding of the ASD should be establishe...