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S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors

We evaluated the hCA (CA, EC 4.2.1.1) inhibitory activity of novel 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides (compounds 2-20) towards the isoforms I, II, IX, and XII. hCA Isoforms were effectively inhibited by most of new compounds comparable to those of AAZ. Compou...

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Main Authors:	Adel S. El-Azab (Author), Alaa A.-M (Author), Silvia Bua (Author), Alessio Nocentini (Author), Nawaf A. AlSaif (Author), Mohammed M. Alanazi (Author), Manal A. El-Gendy (Author), Hany E. A. Ahmed (Author), Claudiu T. Supuran (Author)
Format:	Book
Published:	Taylor & Francis Group, 2020-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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