Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation.

• Main Authors: Shelley F Stone (Author), Geoffrey K Isbister (Author), Seyed Shahmy (Author), Fahim Mohamed (Author), Chandana Abeysinghe (Author), Harendra Karunathilake (Author), Ariaranee Ariaratnam (Author), Tamara E Jacoby-Alner (Author), Claire L Cotterell (Author), Simon G A Brown (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Snake bite is one of the most neglected public health issues in poor rural communities worldwide. In addition to the clinical effects of envenoming, treatment with antivenom frequently causes serious adverse reactions, including hypersensitivity reactions (including anaphylaxis) and pyro...