Iron therapy for iron-deficiency anemia and pelvic inflammatory disease

• প্রধান লেখক: Khaiatova Z.B (Author), Abdukadirova N.B (Author), A.V. Yakimova (Author), Shpagina L.A (Author), Sokolova T.M (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: LCC «Medicine-Inform», 2019-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

সংক্ষিপ্ত

<b>Iron therapy for iron-deficiency anemia and pelvic inflammatory disease<br> </b><br> Z.B. Khaiatova¹, N.B. Abdukadirova², A.V. Yakimova¹, L.A. Shpagina¹, T.M. Sokolova^1<br><br> ¹Novosibirsk State Medical University, Novosibirsk, Russian Federation<br> ²Samarkand State Medical Institute, Samarkand, Uzbekistan<br> <br> <b>Aim</b>: To assess the efficacy of two-step treatment for iron-deficiency anemia in women of reproductive age with pelvic inflammatory disease (PID).<br> <b>Patients and Methods:</b> 320 women with iron-deficiency anemia and pelvic inflammatory disease were subdivided into two groups depending on the treatment. Group I included 160 women who received traditional therapy, i.e., complex treatment for pelvic inflammatory disease plus Tardyferon^® for iron-deficiency anemia. Group II included 160 women who received stepwise treatment. Step 1 was complex treatment for pelvic inflammatory disease only. After the inflammation has reduced and iron-deficiency anemia was verified, the patients were prescribed (on average, after 12.2±1.1 days) with Tardyferon^® (step 2).<br> <b>Results</b>: Serum tests have demonstrated that these women are characterized by high activity of free radical processes which illustrate active inflammation. After 10 days of the treatment, the ratio of pro-oxidant and antioxidant activities was significantly less in group I than in group II. Moreover, in group I this ratio has significantly increased. In group I, the result of the treatment was increased pro-oxidant potential. Reduced serum antioxidant activity has resulted in the oxidative stress. After 30 days, average hemoglobin, serum iron, and serum ferritin in group II women with iron-deficiency anemia (both stage 1 and 2) were significantly higher than in group I women. Despite complex anti-inflammatory treatment for PID, vaginitis was diagnosed in 20.6% (n=33) in group I.<br> <b>Conclusions</b>: Two-step treatment for iron-deficiency anemia in women with PID using Tardyferon^®is highly effective which is illustrated by the normalization of ferrokinetic parameters, decrease in pro-oxidant activity, less common (by 3.1 times) inflammatory signs, and less common (by 2.1 times) iron deficiency signs.<br> <br> <b>Keywords</b>: iron-deficiency anemia, ferritin, pelvic inflammatory disease.<br> <b>For citation: </b>Khaiatova Z.B., Abdukadirova N.B.,Yakimova A.V. et al. Iron therapy for iron-deficiency anemia and pelvic inflammatory disease. Russian Journal of Woman and Child Health. 2019;2(2):108-112.<br>

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