Synthesis and biological evaluation of fused dipyranoquinolinones as inhibitors of acetylcholinesterase with antioxidant properties
Bis-fused pyridopyranocoumarins are prepared in excellent yields through the triple bond activation of propargylaminopropargyloxycoumarins or propargylamino (Kontogiorgis et al., 2012; Zhang et al., 2014) [7,8]-fused pyranocoumarins by gold nanoparticles supported on TiO2 under microwave irradiation...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Book |
| Published: |
Elsevier,
2022-08-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Bis-fused pyridopyranocoumarins are prepared in excellent yields through the triple bond activation of propargylaminopropargyloxycoumarins or propargylamino (Kontogiorgis et al., 2012; Zhang et al., 2014) [7,8]-fused pyranocoumarins by gold nanoparticles supported on TiO2 under microwave irradiation. The intermediate new propargylaminopropargyloxycoumarins are synthesized through propargylation of 6-amino-7-hydroxycoumarins or 6-amino-4-hydroxycoumarin. Preliminary biological tests indicated remarkable antioxidant and anti-AChE activities of the new compounds and especially for 16a and 19b which present also druglikeness following the rule of five. |
|---|---|
| Item Description: | 2772-4174 10.1016/j.ejmcr.2022.100063 |