Evaluation of Hemopoietic Disorders and Renal Function in Children with Chronic Glomerulonephritis Depending on Allelic Gene Polymorphism of IL-10 and IL-1β
We have examined 20 children suffering from chronic glomerulonephritis with torpid course of disease and persistent urinary syndrome. It was defined that in children with torpid course of disease genotype C/T gene IL-1β (-511) (p < 0.05) was significantly more common. Also, we found the relations...
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| Format: | Book |
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Zaslavsky O.Yu.,
2012-03-01T00:00:00Z.
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| Summary: | We have examined 20 children suffering from chronic glomerulonephritis with torpid course of disease and persistent urinary syndrome. It was defined that in children with torpid course of disease genotype C/T gene IL-1β (-511) (p < 0.05) was significantly more common. Also, we found the relationship between allelic variants of cytokines genes and parameters of GFR and endogenous erythropoietin. In children with genotype C/T IL-1β (-511) has been a significant reduction of erythropoietin even in the absence of anemia and iron deficiency (p < 0.05). In identifying the genotype G/G IL-10 (-1082) and C/T, C/C genotype of IL-1β (-511) 1.2-fold lower GFR was observed (p < 0.05). |
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| Item Description: | 2224-0551 2307-1168 10.22141/2224-0551.0.3.38.2012.100651 |