Dimethylsphingosine Regulates Intracellular pH and Ca2+ Human Monocytes

• Main Authors: Eun-Hee Lee (Author), Yun-Kyung Lee (Author), Young-Jin Im (Author), Jae-Ho Kim (Author), Fumikazu Okajima (Author), Dong-Soon Im (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Dimethylsphingosine (DMS) was first reported as an inhibitor of protein kinase C and later has been used as a specific inhibitor of sphingosine kinase. Furthermore, its anti-cancer effect has become a basis for development of chemotherapy. Nevertheless, its anti-neoplastic mechanism has p...