Evaluation of the Pharmacological Profile of Ramosetron, a Novel Therapeutic Agent for Irritable Bowel Syndrome

• Autori principali: Takuya Hirata (Autore), Yoshihiro Keto (Autore), Toshiyuki Funatsu (Autore), Shinobu Akuzawa (Autore), Masao Sasamata (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2007-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We examined the pharmacological profile of ramosetron, a 5-HT3-receptor antagonist for irritable bowel syndrome with diarrhea, comparing it with those of other 5-HT3-receptor antagonists, alosetron and cilansetron, and the anti-diarrheal agent loperamide. Ramosetron showed high affinity for cloned h...