Shigella-mediated immunosuppression in the human gut: subversion extends from innate to adaptive immune responses

The enteropathogen, Shigella, is highly virulent and remarkably adjusted to the intestinal environment of its almost exclusive human host. Key for Shigella pathogenicity is the injection of virulence effectors into the host cell via its type three secretion system (T3SS), initiating disease onset an...

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Main Authors: Katja Brunner (Author), Fatoumata Samassa (Author), Philippe J. Sansonetti (Author), Armelle Phalipon (Author)
Format: Book
Published: Taylor & Francis Group, 2019-06-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Katja Brunner  |e author 
700 1 0 |a Fatoumata Samassa  |e author 
700 1 0 |a Philippe J. Sansonetti  |e author 
700 1 0 |a Armelle Phalipon  |e author 
245 0 0 |a Shigella-mediated immunosuppression in the human gut: subversion extends from innate to adaptive immune responses 
260 |b Taylor & Francis Group,   |c 2019-06-01T00:00:00Z. 
500 |a 2164-5515 
500 |a 2164-554X 
500 |a 10.1080/21645515.2019.1594132 
520 |a The enteropathogen, Shigella, is highly virulent and remarkably adjusted to the intestinal environment of its almost exclusive human host. Key for Shigella pathogenicity is the injection of virulence effectors into the host cell via its type three secretion system (T3SS), initiating disease onset and progression by the vast diversity of the secreted T3SS effectors and their respective cellular targets. The multifaceted modulation of host signaling pathways exerted by Shigella T3SS effectors, which include the subversion of host innate immune defenses and the promotion of intracellular bacterial survival and dissemination, have been extensively reviewed in the recent past. This review focuses on the human species specificity of Shigella by discussing some possible evasion mechanisms towards the human, but not non-human or rodent gut innate defense barrier, leading to the lack of a relevant animal infection model. In addition, subversion mechanisms of the adaptive immune response are highlighted summarizing research advances of the recent years. In particular, the new paradigm of Shigella pathogenicity constituted of invasion-independent T3SS effector-mediated targeting of activated, human lymphocytes is discussed. Along with consequences on vaccine development, these findings offer new directions for future research endeavors towards a better understanding of immunity to Shigella infection. 
546 |a EN 
690 |a adaptive immunity 
690 |a enteropathogen 
690 |a type three secretion system 
690 |a dysentery 
690 |a immunomodulation 
690 |a t cells 
690 |a bacterial 
690 |a bacterial mucosal 
690 |a immune modulators 
690 |a infectious disease 
690 |a mucosal 
690 |a virulence 
690 |a Immunologic diseases. Allergy 
690 |a RC581-607 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Human Vaccines & Immunotherapeutics, Vol 15, Iss 6, Pp 1317-1325 (2019) 
787 0 |n http://dx.doi.org/10.1080/21645515.2019.1594132 
787 0 |n https://doaj.org/toc/2164-5515 
787 0 |n https://doaj.org/toc/2164-554X 
856 4 1 |u https://doaj.org/article/39b03b5d0f1f4e53b178a8c45d8efd5d  |z Connect to this object online.