Imiquimod liposome gel preparations and their ability to inhibit hypertrophic scars
[Abstract]: Objective: This study evaluates the efficacy of imiquimod liposome gel (IMQ-Lips gel) to prevent and treat hypertrophic scars (HS). Methods: On the basis of an orthogonal L9 (34) design, IMQ-Lips formulations were optimized using the film dispersion-pH gradient method. The optimal parame...
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| Main Authors: | , , , , , |
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| Format: | Book |
| Published: |
KeAi Communications Co., Ltd.,
2021-06-01T00:00:00Z.
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| Summary: | [Abstract]: Objective: This study evaluates the efficacy of imiquimod liposome gel (IMQ-Lips gel) to prevent and treat hypertrophic scars (HS). Methods: On the basis of an orthogonal L9 (34) design, IMQ-Lips formulations were optimized using the film dispersion-pH gradient method. The optimal parameters were phospholipid-cholesterol (3 : 1), lipid-to-drug ratio (8 : 1), and a vitamin E of 5 mg. The in vitro transdermal experiment and rabbit HS model were used to evaluate the pharmacodynamics in vitro and in vivo. Results: IMQ-Lips has good physical and chemical properties, with an encapsulation rate of 81.2% ± 1.9%, an average diameter of (347 ± 21) nm, and a zeta potential of (-12.19 ± 1.7) mV. In vitro transdermal penetration tests showed that IMQ-Lips gel enhanced skin retention and reduced transdermal delivery compared with IMQ gel. The rabbit HS model further revealed that IMQ-Lips gel treatment reduced scar formation by inhibiting overproliferation of fibroblasts and reducing interleukin-4 levels. Conclusion: Taken together, these data suggest that IMQ-Lips gel represents a potential therapeutic approach for HS treatment. |
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| Item Description: | 2707-3688 10.1016/S2707-3688(23)00015-8 |