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Dalzanemdor (SAGE‐718), a novel, investigational N‐methyl‐D‐aspartate receptor positive allosteric modulator: Safety, tolerability, and clinical pharmacology in randomized dose‐finding studies in healthy participants and an open‐label study in participants with Huntington's disease

Abstract N‐methyl‐D‐aspartate receptor (NMDAR)‐positive allosteric modulators (PAMs) represent a potential therapeutic strategy for cognitive impairment in disorders associated with NMDAR hypofunction, including Huntington's disease (HD) and Alzheimer's disease. Dalzanemdor (SAGE‐718) is a...

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Main Authors:	Aaron Koenig (Author), Michael Lewis (Author), Jeff Wald (Author), Sigui Li (Author), Mustafa Varoglu (Author), Jing Dai (Author), Abdul Sankoh (Author), Katrina Paumier (Author), James Doherty (Author), Mike Quirk (Author)
Format:	Book
Published:	Wiley, 2024-07-01T00:00:00Z.
Subjects:	article
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